The Sauer Laboratory for Structural Biology’s ultra-low-temperature electron microscopes and the Texas Advanced Computing Center’s Frontera supercomputer continue to help researchers gain a better understanding of the disease and treatment. The Texas Department of State Health Services has designated UT as a vaccine hub for Texas. Along with researchers at the National Institutes of Health, UT’s Jason McLellan and his team have made key discoveries, which major drug companies have used to develop vaccines. Coronavirus research has made progress thanks to UT Austin’s access to technology and equipment funded by the Cancer Prevention and Research Institute of Texas. UT Austin is among the top universities in the nation for pandemic research and has played a crucial role in protecting against the virus. To that end, the university set up a licensing arrangement that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties. The vaccine, called NDV-HXP-S, is the result of a partnership between UT Austin, the Icahn School of Medicine at Mount Sinai in New York and global partners interested in advancing the supply of affordable vaccines to address the pandemic. Research by Jason McLellan, a structural biologist at UT Austin, and his team is aiding the development of these HexaPro-based vaccines, based on a more rugged and stable protein that is better able to withstand heat and better equipped for distribution to lower-income countries. In a major boost to efforts to combat COVID-19 globally, a vaccine that recently entered human trials in Vietnam and Thailand and is slated for a clinical study in Brazil, holds promise for affordable vaccine manufacturing in countries currently dependent on imported vaccines. When UT Austin researchers like Jason McLellan realized their work could make a difference in real-world health situations, they felt obligated to translate their findings into something that might help people and teamed up with the Icahn School of Medicine at Mount Sinai to develop an affordable, stable vaccine in an egg.
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